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KMID : 1200020140380030181
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Diabetes & Metabolism Journal
2014 Volume.38 No. 3 p.181 ~ p.186
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The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
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Lee In-Kyu
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Abstract
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The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.
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KEYWORD
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Diabetes mellitus, Obesity, Pyruvate dehydrogenase (acetyl-transferring) kinase
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